Major structural proteins of type B, type C, and type D oncoviruses share interspecies antigenic determinants.

Interspecies antigenic determinants have been used as markers to study the evolution of oncoviruses. By radioimmunologic techniques, it has been possible to detect crossreactivities among the major structural proteins of prototype viruses representing each of the three major Oncovirinae genera. Two different subsets of interspecies antigenic determinants were demonstrated. One encompasses known type B and type D viruses; the other is shared by type D and mammalian type C viruses. Such determinants were also demonstrated in certain as yet unclassified oncoviruses. These findings provide experimental evidence supporting the concept of an evolutionary relationship among the three major oncovirus genera.